One of the serious disorders of the human body includes cancer. It is the abnormal proliferation of the otherwise normal cells in the body. The disease is curable through modern medications including at the top Nolvadex of ICI pharmaceuticals. Chemically called as Tamoxifen, its use for the treatment of breast cancer and infertility is popular among the physicians.
Principally, the medicine is an estrogen antagonist for the tissues of breast. It binds the ER, estrogen receptors on the breast cells and blocks the DNA synthesis in the cells and thereby prevents further proliferation of the cells. It is not a catabolic drug rather it is a preventive drug causing cytostasis. It freezes the proliferation of the cancerous cells at their Go and G1 stages of mitosis.
Popular among heavy-weight athletes, the drug is capable of increasing the testosterone level and decreasing the estrogenic activity simultaneously, thereby, reducing the chances of breast carcinoma in the athletes and body builders. The testosterone has its production increased by the drug but its degradation to estrogen is also increased which raises the cancer possibility. This effect is again counter balanced by the drug as it competes with estrogen effectively for the receptors.
In case of infertility of both post- and pre-menopausal women, the drug is considered as an effective estrogen agonist for their treatment. Moreover, it is observed to reduce osteoporosis due to its estrogen agonistic effect of inhibiting osteoclasts in older women. The dug is commonly prescribed in the dosages of 10-40mg from 3rd to 4th day of period. For males, as in the case of gynaecomastia, the dosage should not exceed 20mg per day.
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